Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish.

Ryuji OkamotoItaru GotoYuhei NishimuraIssei KobayashiRyotaro HashizumeYoshinori YoshidaRie ItoYuhko KobayashiMisato NishikawaYusuf AliShunsuke SaitoToshio TanakaYoshiki SawaMasaaki ItoKaoru Dohi

Published in: PloS one (2020)

These results indicate both that GJB4 is defined as a new connexin in diseased hearts, of which mutation can cause a familial form of HCM, and that GJB4 may be a new target for the treatment of cardiac hypertrophy and dysfunction.

Keyphrases

hearing loss
oxidative stress
hypertrophic cardiomyopathy
heart failure
binding protein