A quantitative pharmacology model for cannabinoid receptor type 1 (CB 1 ) mediated by Gi/Gs protein competition.

Liang YangDavid B FinlayHayley M GreenXiao ZhuMichelle GlassStephen Duffull

Published in: British journal of pharmacology (2023)

regulated Gi/Gs pathways was developed. It indicated Hypothesis 1 is feasible and G protein pre-coupling is a key step causing cAMP signalling switch. The model-designed experiments provided guides for future experimentation research.

Keyphrases

binding protein
transcription factor
high resolution
room temperature
mass spectrometry