CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.

Mathieu SeyfridWilliam Thomas MaichVaseem Muhammad ShaikhNazanin TatariDeepak UpretiDeween PiyasenaMinomi SubapandithaNeil SavageDillon McKennaNicholas MikolajewiczHong HanChirayu ChokshiLaura KuhlmannAmanda KhooSabra Khalid SalimBlessing Archibong-BasseyWilliam GwynneKevin BrownNadeem MurtazaDavid BakhshinyanParvez VoraChitra VenugopalJason MoffatThomas KislingerSheila K Singh

Published in: Journal for immunotherapy of cancer (2022)

CD70 plays a key role in recurrent GBM cell aggressiveness and maintenance. Immunotherapeutic targeting of CD70 significantly improves survival in animal models and the CD70/CD27 axis may be a viable polytherapeutic avenue to co-target both GBM and its TIME.

Keyphrases

nk cells
single cell
cell therapy
cancer therapy
bone marrow