Hepatoprotective standardized EtOH-water extract of the leaves of Ziziphus jujuba.
Lu BaiXueqin CuiNi ChengWei CaoYong WuSen GuoLi ZhangChi-Tang HoNai-Sheng BaiPublished in: Food & function (2017)
The hepatoprotective activity of the EtOH-water extract of Ziziphus jujuba leaves was evaluated against CCl4-induced hepatic damage in mice. The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum ALT and AST and the decreased MDA content, the increased levels of SOD, GSH and GSH-Px, and the reduced pathological tissue injury induced by CCl4. A quantitative analysis of fifteen major constituents (1-15) of the EtOH-water extract of the leaves of Z. jujuba was conducted by HPLC-DAD. Based on our research results, it can be concluded that the EtOH-water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of CCl4-induced hepatic injury in mice. Flavonoids might be the active ingredients responsible for the biological and pharmacological activities towards hepatoprotection.
Keyphrases
- oxidative stress
- diabetic rats
- anti inflammatory
- ms ms
- liver injury
- drug induced
- essential oil
- simultaneous determination
- high resolution
- mass spectrometry
- liver fibrosis
- high fat diet induced
- insulin resistance
- breast cancer cells
- skeletal muscle
- fluorescent probe
- cell proliferation
- endothelial cells
- tandem mass spectrometry