Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.

Andrea R WaksmunskiMichelle GruninTyler G KinzyRobert P IgoJonathan L HainesJessica N Cooke Bailey

Published in: BMC medical genomics (2020)

Pathway analyses, which leverage biological relationships among genes in a pathway, may be useful in identifying additional loci that contribute to the heritability of complex disorders in a non-additive manner. Heritability analyses of these loci, especially amongst disease subtypes, may provide clues to the importance of specific genes to the genetic architecture of AMD.

Keyphrases

genome wide
age related macular degeneration
dna methylation
bioinformatics analysis
copy number
genome wide association
gene expression
genome wide analysis