CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Lennart LenkMichela CarletFotini VogiatziLea SporyDorothee WinterbergAntony F CousinsMichaela Vossen-GajcyOlta IbruliChristian VokuhlGunnar CarioOmar El AyoubiLisa KramerMatthias RitgenMonika BrüggemannRobert HäslerMartin SchrappeStephan FuhrmannChristina HalseyIrmela JeremiasElias HobeikaHassan JumaaAmeera AlsadeqDenis Martin SchewePublished in: Communications biology (2021)
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Keyphrases
- acute lymphoblastic leukemia
- blood brain barrier
- end stage renal disease
- acute myeloid leukemia
- bone marrow
- allogeneic hematopoietic stem cell transplantation
- chronic kidney disease
- newly diagnosed
- ejection fraction
- induced apoptosis
- nk cells
- cell proliferation
- prognostic factors
- single cell
- young adults
- hematopoietic stem cell