Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.

Bang-Hong ZhangLin-Sheng LeiSi-Zhan LiuXue-Qing MouWei-Ting LiuShao-Hua WangJie WangWen BaoKun Zhang

Published in: Chemical communications (Cambridge, England) (2018)

A Zn(OTf)2-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.

Keyphrases

molecular docking
heavy metals
risk assessment
molecular dynamics simulations
oxide nanoparticles