Comparative Study of Porous Iron Foams for Biodegradable Implants: Structural Analysis and In Vitro Assessment.
Gabriela GąsiorMarlena GrodzickaTomasz JędrzejewskiWiśniewski MarekAleksandra RadtkePublished in: Journal of functional biomaterials (2023)
Biodegradable metal systems are the future of modern implantology. This publication describes the preparation of porous iron-based materials using a simple, affordable replica method on a polymeric template. We obtained two iron-based materials with different pore sizes for potential application in cardiac surgery implants. The materials were compared in terms of their corrosion rate (using immersion and electrochemical methods) and their cytotoxic activity (indirect test on three cell lines: mouse L929 fibroblasts, human aortic smooth muscle cells (HAMSC), and human umbilical vein endothelial cells (HUVEC)). Our research proved that the material being too porous might have a toxic effect on cell lines due to rapid corrosion.
Keyphrases
- endothelial cells
- drug delivery
- cardiac surgery
- molecularly imprinted
- iron deficiency
- metal organic framework
- highly efficient
- acute kidney injury
- gold nanoparticles
- molecular dynamics
- soft tissue
- molecular dynamics simulations
- drug release
- vascular endothelial growth factor
- current status
- extracellular matrix
- mass spectrometry
- human health
- ionic liquid
- risk assessment
- sensitive detection
- liquid chromatography