Fibroblast-enhanced cyclophilin A releasing from U937 cell upregulates MMP-2 in gingival fibroblast.

Po-Jan KuoChi-Yu LinTzu-Ying ChenTsung-Fu HungHsiao-Lun LinHsien-Chung ChiuCheng-Yang ChiangFu-Gong LinEarl Fu

Published in: Journal of periodontal research (2020)

Based on the present findings, we suggest that gingival fibroblasts could enhance the CyPA release from U937 cells, via the JNK pathway, resulting in MMP-2 enhancement in fibroblasts. The finding shed light on a new mechanism of cellular interaction involving MMP-2 and CyPA, in two cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
cell migration
oxidative stress
single cell
cell therapy
pi k akt
cell proliferation
bone marrow