Palladium-Catalyzed Electrochemical Iodination of 1-Arylpyridine N -Oxides.

The palladium-catalyzed C-H iodination of 1-arylpyridine N -oxides proceeded under electrochemical oxidation conditions using I 2 as an iodine source. The reaction of isoquinoline N -oxides possessing various para - or meta -substituted aryl groups at the 1-position proceeded to give the corresponding iodination products. Electron-donating groups on the aryl group facilitated the reaction to give relatively high yields of the product. The reaction was also found to be applicable to 2-aryl-3-picoline N -oxides.