Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation.

Jiangang SunDandan ShenYongshun GaoYi-Chao ZhengLijuan ZhaoMamum MaaHongmin LiuXiaoping Chen

Published in: OncoTargets and therapy (2020)

Down-regulation of USP8 inhibits HER-3 positive GC cells proliferation in vivo and in vitro, which indicate that USP8 represents a feasible choice as a therapeutic target for HER-3 positive GC cells.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
pi k akt
decision making
simultaneous determination