Deep brain stimulation in five patients with severe disorders of consciousness.

Jean-Jacques LemaireAnna SontheimerBruno PereiraJérôme CosteSarah RosenbergCatherine SarretGuillaume CollJean GabrillarguesBetty JeanThierry GillartAurélien CosteBasile RocheAntony KellyBénédicte PontierFabien Feschet

Published in: Annals of clinical and translational neurology (2018)

Our findings show there were robust but limited individual clinical benefits, mainly in visual and auditory processes. Overall modifications seem linked to the modulation of thalamo-cortico-basal and tegmental loops activating default mode network cortices. Specifically, in the two responders there was an increase in medial cortex activity related to internal awareness.

Keyphrases

deep brain stimulation
parkinson disease
functional connectivity
obsessive compulsive disorder
resting state
signaling pathway
early onset
working memory
drug induced
hearing loss