Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood.
Alexander NeumannAlexia Jolicoeur-MartineauEszter SzekelyHannah M SallisKieran O'DonnelCelia M T GreenwoodRobert LevitanMichael J MeaneyAshley WazanaJonathan EvansHenning TiemeierPublished in: Journal of child psychology and psychiatry, and allied disciplines (2021)
The results suggest that PRSs based on current GWASs of psychiatric phenotypes tend to be associated with general psychopathology, or both general and specific psychiatric domains, but not with one specific psychopathology domain only. Furthermore, PRSs can be combined to improve predictive ability. PRS users should therefore be conscious of nonspecificity and consider using multiple PRSs simultaneously, when predicting psychiatric disorders.