Effect of maternal apical periodontitis on the final step of insulin signalling and inflammatory pathway in the adult male offspring of rats.
Thaís Verônica Saori TsosuraMaria Sara de Lima Coutinho MatteraFernando Yamamoto ChibaAna Carolina Nascimento CarnevaliBianca Elvira BelardiRodrigo Martins Dos SantosLuciano Tavares Angelo CintraFlavia Lombardi LopesNatália Francisco ScarameleDóris Hissako MatsushitaPublished in: International endodontic journal (2021)
Maternal AP in four teeth was associated with impairment in the final step of insulin signalling in the GM of adult male offspring in rats. An increase in NF-κB activity may be involved in this decrease in insulin signalling. This study demonstrates the impact of maternal AP on the health of offspring, demonstrating the importance of maintaining adequate maternal oral health to prevent diseases in adult offspring in rats.
Keyphrases
- type diabetes
- high fat diet
- birth weight
- pregnancy outcomes
- oral health
- healthcare
- transcription factor
- glycemic control
- public health
- signaling pathway
- mental health
- gestational age
- weight gain
- childhood cancer
- insulin resistance
- pregnant women
- physical activity
- risk assessment
- nuclear factor
- social media
- inflammatory response
- pi k akt
- preterm birth