18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells.

Ying-Hua LuoCheng WangWan-Ting XuYu ZhangTong ZhangHui XueYan-Nan LiZhong-Ren FuYing WangCheng-Hao Jin

Published in: OncoTargets and therapy (2021)

In summary, 18β-Gly induced apoptosis and G2/M cell cycle arrest and inhibited migration via the ROS/MAPK/STAT3/NF-κB signaling pathways in A549 lung cancer cells. Therefore, 18β-Gly is a novel promising candidate for the treatment of lung cancer.

Keyphrases

cell cycle arrest
signaling pathway
pi k akt
induced apoptosis
cell death
epithelial mesenchymal transition
cell proliferation
endoplasmic reticulum stress
oxidative stress
dna damage