Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis.

Fabio Alessandro FacchiniDavide Di FuscoSimona BarresiAndrea LuraghiAlberto MinottiFrancesca GranucciGiovanni MonteleoneFrancesco PeriIvan Monteleone

Published in: European journal of clinical pharmacology (2020)

This study suggests that TLR4 chemical modulation can be an effective therapeutic approach to IBD. The selectivity of FP7 on TLR4 makes this molecule a promising drug lead for new small molecules-based treatments.

Keyphrases

toll like receptor
ulcerative colitis
inflammatory response
nuclear factor
immune response
emergency department
structural basis