Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii.

Qing ZhaoJie-Jie GaoXu-Jie Qin Xiao-Jiang HaoHong-Ping HeHai-Yang Liu

Published in: Organic letters (2018)

Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively.

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