Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants.

Shih-Han KoWan-Yu ChenShih-Chieh SuHsiu-Ting LinFeng-Yi KeKang-Hao LiangFu-Fei HsuMonika KumariChi-Yu FuHan-Chung Wu

Published in: Journal of biomedical science (2022)

Since there are not many mAbs that can bind the S2 subunit of SARS-CoV-2 variants, our set of B-S2-mAbs may provide important materials for basic research and potential clinical applications. Importantly, our study results demonstrate that the viral S2 subunit can be targeted for the production of cross-reactive antibodies, which may be used for coronavirus detection and neutralization.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
protein kinase
gene expression
human health
amino acid
risk assessment
real time pcr
climate change
coronavirus disease