The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
Nelson O GekaraHui JiangPublished in: Science signaling (2019)
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.
Keyphrases
- innate immune
- circulating tumor
- cell free
- protein kinase
- single molecule
- immune response
- papillary thyroid
- nitric oxide
- single cell
- cell therapy
- oxidative stress
- hydrogen peroxide
- squamous cell
- nucleic acid
- circulating tumor cells
- squamous cell carcinoma
- binding protein
- protein protein
- bone marrow
- small molecule
- mesenchymal stem cells