Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes.

Adrien JosephStéphanie HarelLaurent MesnardCédric RafatSilène KnappAnne RumplerCarole PhilipponnetChristophe BarbaJean-Michel RebibouDavid BuobAlexandre HertigJacques VargaftigJean-Michel HalimiBertrand ArnulfAnne-Sophie BretaudBérangère JolySteven GrangéPaul Coppo

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)

This study is the largest case series of CFZ-TMA since its approval in 2012. Patients present with severe AKI and experience frequent sequelae. Complement variants and blockade therapy do not seem to play a role in the pathophysiology and prognosis of the disease.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
acute kidney injury
peritoneal dialysis
prognostic factors
early onset
copy number
multiple myeloma
gene expression
skeletal muscle
mesenchymal stem cells
cell therapy
smoking cessation