HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT.
Tao HuangTiange WangYoriko HeianzaDianjianyi SunKerry IveyRonen DurstDan SchwarzfuchsMeir J StampferGeorge A BrayFrank M SacksIris ShaiLu QiPublished in: Diabetes, obesity & metabolism (2018)
Our replicable findings provide strong evidence that individuals with the HNF1A rs7957197 T allele might obtain more benefits in weight loss and improvement of insulin resistance by choosing a hypocaloric and high-fat diet.
Keyphrases
- weight loss
- high fat diet
- insulin resistance
- bariatric surgery
- adipose tissue
- roux en y gastric bypass
- metabolic syndrome
- skeletal muscle
- gastric bypass
- polycystic ovary syndrome
- nuclear factor
- type diabetes
- high fat diet induced
- study protocol
- phase iii
- glycemic control
- weight gain
- clinical trial
- phase ii
- obese patients
- immune response
- toll like receptor
- open label