The structural maintenance of chromosomes 5 is a possible biomarker for individualized treatment of colorectal cancer.
Xiaoxia GongXiaowei TianHao XieZhaoshui LiPublished in: Cancer medicine (2022)
SMC5 is a tumor suppressor, that low expression of this gene is benefit for the development of CRC. Combination treatment with RTX and OXA may be more suitable for those OXA no-responders with lower SMC5.