Mouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function.

Wei XuYunting ZhouTianyuan WangChengming NiChunlei WangRui LiXuekui LiuJun LiangTzu-Wen HongLiu Bo Aileen J F KingShanta J PersaudZi-Lin Sun Peter M Jones

Published in: Diabetic medicine : a journal of the British Diabetic Association (2024)

ISCs are a specific sub-type of islet-derived stromal cells that possess biological behaviors distinct from MSCs. The enhanced beneficial effects of ISCs on islet beta cell function suggests that they may offer a therapeutic target for enhancing beta cell functional survival in diabetes.

Keyphrases

induced apoptosis
type diabetes
cardiovascular disease
mesenchymal stem cells
bone marrow
single cell
cell cycle arrest
cell therapy
metabolic syndrome
cell death
glycemic control
insulin resistance
umbilical cord