Skin Antisepsis before Surgical Fixation of Extremity Fractures.
null nullSheila SpragueGerard SlobogeanJeffrey L WellsNathan N O'HaraLehana ThabaneC Daniel MullinsAnthony D HarrisAmber WoodDarius ViskontasKelly L ApostleRobert V O'TooleManjari JoshiHerman JohalJamal Al-AsiriRobert A HymesGreg E GaskiHolly T PilsonEben A CarrollSharon BabcockJason J HalvorsonNicholas M RomeoChristopher A MatsonThomas F HigginsLucas S MarchandPatrick F BerginJohn MorellatoRobert E Van DemarkG David PotterI Leah GitajnGerard ChangKevin D PhelpsLaurence B KemptonMadhav KarunakarTodd JaeblonHaley K DemyanovichChristopher M DomesGabrielle R KuhnRachel M ReillyMark J GageMichael J WeaverArvind G von KeudellMarilyn HengMichael F McTagueAhmad AlnasserSamir MehtaDerek J DoneganRoman Michael NatoliJan SzatkowskiAlesha N ScottSteven F ShannonKyle J JerayStephanie L TannerMeir T MarmorAmir MatityahuJustin T FowlerSarah N PierrieMichael J BeltranCameron G ThomsonCarol A LinCharles N MoonJohn A ScolaroArya AmirhekmatJordan LeonardDavid PogorzelskiSofia BzovskyDiane Heels-AnsdellOlivia P SzaszJodi L GallantGregory J Della RoccaRobert D ZuraJoan N HebdenJoseph T PattersonChristopher LeeLyndsay M O'HaraDebra MarvelJana E PalmerJeff FriedrichJean-Claude G D'AlleyrandJessica C RiveraFranca MossutoGregory M SchrankGordon GuyattPhilip J DevereauxMohit Bhandarinull nullPublished in: The New England journal of medicine (2024)
Among patients with closed extremity fractures, skin antisepsis with iodine povacrylex in alcohol resulted in fewer surgical-site infections than antisepsis with chlorhexidine gluconate in alcohol. In patients with open fractures, the results were similar in the two groups. (Funded by the Patient-Centered Outcomes Research Institute and the Canadian Institutes of Health Research; PREPARE ClinicalTrials.gov number, NCT03523962.).