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Associations between attention-deficit hyperactivity disorder (ADHD) symptom remission and white matter microstructure: A longitudinal analysis.

Anne E M LeendersChristienne G DamatacSourena Soheili-NezhadRoselyne J M ChauvinMaarten J J MennesMarcel P ZwiersDaan van RooijSophie E A AkkermansJilly NaaijenBarbara FrankeJan K BuitelaarChristian F BeckmannEmma Sprooten
Published in: JCPP advances (2021)
In this longitudinal DWI study of ADHD using dimensional symptom scores, we show that greater symptom decrease is associated with lower follow-up FA in specific WM tracts. Altered FA thus may appear to follow, rather than precede, changes in symptom remission. Our findings indicate divergent WM developmental trajectories between individuals with persistent and remittent ADHD, and support the role of prefrontal and sensorimotor tracts in the remission of ADHD.
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