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Sensitivity and specificity of OraQuick® HIV self-test compared to a 4th generation laboratory reference standard algorithm in urban and rural Zambia.

Melissa NeumanAlwyn MwingaKezia KapakuLucheka SigandeCaroline GotscheMiriam TaegtmeyerRussell DacombeKwitaka MaluziBarry KosloffCheryl JohnsonKarin HatzoldElizabeth L CorbettHelen Ayles
Published in: BMC infectious diseases (2022)
Self-testers in Zambia who used OraQuick® HIV Self-Test achieved reasonable clinical performance compared to the national RDT algorithm. However, sensitivity of the self-test was reduced compared to a laboratory reference standard, as was the national RDT algorithm. In-person demonstration, along with the written manufacturer instructions, was needed to obtain accurate results. Programmes introducing self-care diagnostics should pilot and optimise support materials to ensure they are appropriately adapted to context.
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