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The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment.

Anthony CannonAbigail PajulasMark H KaplanJilu Zhang
Published in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (2023)
Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central role in pathologies such as allergic asthma, immunity to parasitic infection, and autoimmunity. More recently, IL-9 has garnered considerable attention in tumor immunity. Historically, IL-9 has been associated with a protumor function in hematological malignancies and an antitumor function in solid malignancies. However, recent discoveries of the dynamic role of IL-9 in cancer progression suggest that IL-9 can act as both a pro- or antitumor factor in various hematological and solid malignancies. This review summarizes IL-9-dependent control of tumor growth, regulation, and therapeutic applicability of IL-9 blockade and IL-9-producing cells in cancer.
Keyphrases
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