Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension.
Kathleen D KolstadAvani KhatriMichele DonatoSarah E ChangShufeng LiVirginia D SteenPaul J UtzPurvesh KhatriLorinda S ChungPublished in: Arthritis research & therapy (2022)
These data suggest that cytokine profiles can distinguish SSc patients who are at high-risk for or have PAH from SSc patients who may be at lower risk for PAH and HC. However, high-risk and PAH patients had very similar cytokine profiles, suggesting that these patients are on a disease continuum.
Keyphrases
- end stage renal disease
- systemic sclerosis
- pulmonary arterial hypertension
- chronic kidney disease
- newly diagnosed
- ejection fraction
- prognostic factors
- pulmonary hypertension
- gene expression
- rheumatoid arthritis
- dna methylation
- interstitial lung disease
- pulmonary artery
- patient reported outcomes
- machine learning
- coronary artery
- polycyclic aromatic hydrocarbons
- idiopathic pulmonary fibrosis
- patient reported