Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes.

Davide RomeresYogesh YadavF N U RuchiRickey E Carter Claudio CobelliRita BasuAnanda Basu

Published in: The Journal of clinical endocrinology and metabolism (2024)

Hyperglycemia modulates lactate metabolism during exercise by lowering CL, leading to higher circulating lactate concentrations in T1D individuals. This novel observation implies that exercise during hyperglycemia can lead to higher circulating lactate concentrations thus increasing the likelihood of reaching the lactate threshold sooner in T1D, and has high translational relevance both for providers and recreationally active people with T1D.

Keyphrases

high intensity
type diabetes
physical activity
resistance training
signaling pathway
cardiovascular disease
metabolic syndrome
insulin resistance
glycemic control
oxidative stress