Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis.

Zhefeng LouWeiwei LinHuirong ZhaoXueli JiaoCong WangHe ZhaoLu LiuYu LiuQipeng XieXing HuangHaishan HuangLingling Zhao

Published in: Cancer cell international (2021)

ALPL specially inhibits the metastasis of LUAD cells by affecting the p-ERK/c-Myc/RhoA axis, providing a theoretical basis for the targeted therapy of clinical LUAD.

Keyphrases

signaling pathway
induced apoptosis
cell proliferation
cell cycle arrest
pi k akt
endoplasmic reticulum stress
cell death