Nanofabrication of chitosan-based dressing to treat the infected wounds: in vitro and in vivo evaluations.
Maryam YousefiRamin GhahremanzadehMohammad-Reza NejadmoghaddamFatemeh Yazdi SamadiSomayeh NajafzadehFereshteh Mohammadi FatidehZohreh MohammadiArash Minai-TehraniPublished in: Future science OA (2024)
Aim: Here, an innovative kind of antibacterial nanocomposite film is developed by incorporating graphene oxide and zinc oxide into chitosan matrix. Materials & methods: Our dressing was fabricated using the solution casting method. Fourier transform infrared spectra and TGA-DTG clearly confirmed the structure of film dressing. Results & conclusion: Our results showed the tensile strength and elongation at the break of the films were 20.1 ± 0.7 MPa and 36 ± 10%, respectively. Our fabricated film could absorb at least three-times the fluid of its dry weight while being biocompatible, antibacterial, non-irritant and non-allergic. In addition, it accelerated the healing process of infected wounds by regulating epithelium thickness and the number of inflammatory cells, thus it may be useful for direct application to damaged infected wounds.
Keyphrases
- wound healing
- reduced graphene oxide
- room temperature
- induced apoptosis
- gold nanoparticles
- ionic liquid
- body mass index
- physical activity
- oxidative stress
- cell cycle arrest
- optical coherence tomography
- silver nanoparticles
- density functional theory
- quantum dots
- signaling pathway
- oxide nanoparticles
- molecular dynamics
- solid phase extraction
- solid state