Maturation of cardioventilatory physiological trajectories in extremely preterm infants.
Debra E Weese-MayerJuliann M Di FioreDouglas E LakeAnna Maria HibbsNelson ClaureJiaxing QiuNamasivayam AmbalavananEduardo BancalariJames S KempAmanda M ZimmetJohn L CarrollRichard J MartinKaty N KrahnAaron HamvasSarah J RatcliffeNarayanan KrishnamurthiPremananda IndicAlaleh DormishianPhyllis A DenneryJ Randall Moormannull nullPublished in: Pediatric research (2023)
Physiologic curves of cardiorespiratory events in extremely preterm-born infants offer (1) objective measures to assess individual patient courses and (2) guides for research into control of ventilation, biomarkers and outcomes. Presented are updated maturational trajectories of apnea, periodic breathing, intermittent hypoxemia, and bradycardia in 717 infants born <29 weeks gestation from the multi-site NHLBI-funded Pre-Vent study. Cardioventilatory events peak during the first month of life but the actual postnatal trajectory is dependent on the type of event, race, sex and use of mechanical ventilation. Different time courses for apnea and periodic breathing suggest different maturational mechanisms.
Keyphrases
- preterm infants
- low birth weight
- mechanical ventilation
- gestational age
- acute respiratory distress syndrome
- intensive care unit
- obstructive sleep apnea
- respiratory failure
- depressive symptoms
- preterm birth
- high intensity
- case report
- positive airway pressure
- body composition
- type diabetes
- skeletal muscle
- metabolic syndrome
- weight loss