Associations between maternal plasma zinc concentrations in late pregnancy and LINE-1 and Alu methylation loci in the young adult offspring.

Amaraporn RerkasemSothida NantakoolBrooke C WilsonAmpica MangklabruksKongsak BoonyapranaiApiwat MutiranguraJosé G B Derraik Kitttipan Rerkasem

Published in: PloS one (2022)

Lower maternal zinc concentrations late in gestation were associated with changes in DNA methylation in later life. Thus, zinc deficiency during pregnancy may induce alterations in total LINE-1 methylation and LINE-1 hypermethylation loci. These results suggest a possible epigenetic link between zinc deficiency during pregnancy and long-term outcomes in the offspring.

Keyphrases

dna methylation
genome wide
oxide nanoparticles
pregnancy outcomes
gene expression
young adults
high fat diet
preterm infants
copy number
genome wide association study
replacement therapy
physical activity
pregnant women
metabolic syndrome