Molecular Changes Implicate Angiogenesis and Arterial Remodeling in Systemic Sclerosis-Associated and Idiopathic Pulmonary Hypertension.
Yuechen ZhouTracy TabibMengqi HuangKe YuanYunhye KimChristina MorseJohn Charles SembratEleanor ValenziRobert A LafyatisPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
These data provide high-resolution insights into the complexity and plasticity of the pulmonary endothelium in SSc-associated PH and idiopathic pulmonary arterial hypertension and provide direct molecular insights into soluble mediators and transcription factors driving PH vasculopathy.
Keyphrases
- pulmonary hypertension
- pulmonary arterial hypertension
- systemic sclerosis
- pulmonary artery
- interstitial lung disease
- high resolution
- transcription factor
- nitric oxide
- endothelial cells
- single molecule
- electronic health record
- rheumatoid arthritis
- big data
- idiopathic pulmonary fibrosis
- deep learning
- wound healing
- data analysis