Rapid synthesis of 3-amino-1 H -isochromene from ortho -ynamidyl het(aryl) aldehyde derivatives.

A simple and original efficient synthesis of 3-amino-1 H -isochromene bearing a bromine atom at the C-1 position via a 6-endo-cyclization approach from in situ generated ortho -ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and with good yields. Original ortho -ynamidyl benzaldehyde compounds were also successfully obtained.