Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18 F-FDG positron emission tomography.
Stephen RankinCaitlin FountainAlastair J GemmellDaire QuinnAlasdair D HendersonJohn McClureSandy SmallBalaji VenugopalPamela McKayPiotr J SlomkaDavid ColvilleMark Colquhoun PetrieGiselle C MeléndezNinian N LangPublished in: bioRxiv : the preprint server for biology (2024)
In a large animal model, anthracycline exposure was associated with aortic fibrosis. In patients with lymphoma, anthracycline exposure was not associated with aortic inflammation.Further research is required to elucidate the mechanisms of anthracycline-related vascular harm.
Keyphrases
- positron emission tomography
- computed tomography
- end stage renal disease
- oxidative stress
- pet ct
- pet imaging
- diffuse large b cell lymphoma
- aortic valve
- ejection fraction
- endothelial cells
- newly diagnosed
- left ventricular
- chronic kidney disease
- pulmonary artery
- prognostic factors
- peritoneal dialysis
- heart failure
- aortic dissection
- induced pluripotent stem cells
- pulmonary hypertension
- patient reported