Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides.
Muzaddid SarkerArdeshir GoliaeiFlorence GolesiMarjorie PoggiAaron A CookMohammad A I KhanBrenda R TempleLucia StefaniniMatthias CanaultWolfgang BergmeierSharon L CampbellPublished in: Journal of thrombosis and haemostasis : JTH (2019)
Our studies identify a novel interaction between an atypical C1 domain and phosphatidylinositol (4,5)-biphosphate and phosphatidylinositol (3,4,5)-triphosphate in cellular membranes, which is critical for Rap1 signaling in health and disease.