Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.
Willemien van ZwolAntoine RimbertJustina C WoltersMarieke SmitVincent W BloksNiels J KloosterhuisNicolette C A HuijkmanMirjam H KosterUmesh TharehalliSimon M de NeckColin BournezMarceline M FuhJeroen KuipersSujith RajanAlain de BruinHenry N GinsbergGerard van WestenM Mahmood HussainLudger SchejaJoerg HeerenPhilip ZimmermanBart van de SluisJan Albert KuivenhovenPublished in: Hepatology (Baltimore, Md.) (2022)
We propose a role for SMLR1 in the trafficking of VLDL from the endoplasmic reticulum to the Cis-Golgi complex. While this study uncovers SMLR1 as a player in the VLDL assembly, trafficking, and secretion pathway, it also shows that NASH can occur with undisturbed glucose homeostasis and atheroprotection.