Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis.

Masaru SamuraKeisuke TakadaNaoki HiroseTakenori KurataFumio NagumoMasaki UchidaJunki InoueKoji TanikawaYuki EnokiKazuaki TaguchiKazuaki MatsumotoTakashi UedaShigeru FujimuraHiroshige MikamoYoshio TakesueKotaro Mitsutake

Published in: British journal of clinical pharmacology (2023)

SD daptomycin was associated with significantly lower treatment success than HD in patients with complicated bacteraemia/infective endocarditis. The CPK elevation should be considered in patients treated with high daptomycin doses.

Keyphrases

methicillin resistant staphylococcus aureus
high dose
low dose
staphylococcus aureus
combination therapy
replacement therapy