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Expanding the Spectrum of EWSR1::CREM Fusion Tumors: An Unusual Pediatric Intranasal Myxoid Tumor.

Shamen KohLavisha S PunjabiKenneth Tou-En ChangNeville Wei Yang TeoConstance Ee Hoon TeoShui Yen SohHenry Kun Kiaang Tan
Published in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2023)
EWSR1::CREM gene fusions are increasingly being recognized in a diverse number of soft tissue tumors, including well-defined entities such as angiomatoid fibrous histiocytoma or clear cell sarcoma, and other unclassifiable tumors. As a group, EWSR1::CREM fused tumors often demonstrate primitive spindle or epithelioid cells, myxoid stroma, and a broad immunophenotype. Herein we present an unusual case of a child diagnosed with an intranasal malignant myxoid tumor harboring an EWSR1::CREM gene fusion. To the best of our knowledge, this is the first case of intranasal myxoid tumor with this particular fusion. Diagnosis and management of the case is discussed.
Keyphrases
  • soft tissue
  • healthcare
  • copy number
  • genome wide
  • induced apoptosis
  • mental health
  • clear cell
  • gene expression
  • cell proliferation
  • transcription factor
  • cell death