Ionized water-soluble organic nanosheets with light/ultrasound dual excitation channels for efficient killing of multidrug-resistant bacteria.
Yufan GuDayong JiangLuoyi WangGuangpeng GaoXu-Hui JinPublished in: Chemical communications (Cambridge, England) (2024)
A novel ionized heavy-atom-free two-dimensional organic nanosheet was prepared and exhibited highly selective generation of singlet oxygen under both light and ultrasound excitation. These ionized nanosheets displayed excellent dispersibility in water and enhanced singlet oxygen production efficiency compared to their non-assembled monomers. Antimicrobial experiments have revealed their potent bactericidal effects on drug-resistant E. coli and S. aureus under both visible light and ultrasound irradiation.
Keyphrases
- drug resistant
- multidrug resistant
- water soluble
- visible light
- acinetobacter baumannii
- magnetic resonance imaging
- energy transfer
- gram negative
- quantum dots
- ultrasound guided
- contrast enhanced ultrasound
- escherichia coli
- staphylococcus aureus
- highly efficient
- molecular dynamics
- single cell
- computed tomography
- pseudomonas aeruginosa
- radiation therapy
- radiation induced
- transition metal