Exploration of Pharmacological Mechanisms of Dapagliflozin against Type 2 Diabetes Mellitus through PI3K-Akt Signaling Pathway based on Network Pharmacology Analysis and Deep Learning Technology.
Jie WuYufan ChenShuai ShiJunru LiuFen ZhangXingxing LiXizhi LiuGuoliang HuYang DongPublished in: Current computer-aided drug design (2024)
Dapagliflozin might treat T2DM mainly by targeting AKT1, HSP90AA1, RELA, ITGB1, and TP53 through PI3K-Akt signaling.
Keyphrases
- pi k akt
- signaling pathway
- cell proliferation
- deep learning
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- glycemic control
- heat shock protein
- heat stress
- artificial intelligence
- convolutional neural network
- type diabetes
- machine learning
- metabolic syndrome
- cell death
- adipose tissue
- skeletal muscle
- endoplasmic reticulum stress