Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.

Xiajie ShiFeng ShaoZhixia LiLin KangJunbin LiuStephan KisslerZhiguang ZhouLijing JiaPeilin Zheng

Published in: Endocrine (2019)

Our study constitutes the first functional study of Ptpn22 in B cells in NOD mice. Our findings suggest that Ptpn22 variation contributes to T1D by modifying the B cell compartment and support a gain-of-function for the PTPN22 disease variant.

Keyphrases

type diabetes
high fat diet induced
skeletal muscle
glycemic control
weight loss