Severe Intermittent Hypoxia Modulates the Macrophage Phenotype and Impairs Wound Healing Through Downregulation of HIF-2α.

Lihong ChenYunyi GaoYan LiChun WangDawei ChenYun GaoXing-Wu Ran

Published in: Nature and science of sleep (2022)

Severe intermittent hypoxia could lead to M1 but not M2 macrophage polarization through downregulation of HIF-2α, and then lead to impaired wound healing.

Keyphrases

wound healing
endothelial cells
cell proliferation
early onset
high intensity
signaling pathway
adipose tissue