Age-Related Change in Hepatic Clearance Inferred from Multiple Population Pharmacokinetic Studies: Comparison with Renal Clearance and Their Associations with Organ Weight and Blood Flow.

Kuretake SoejimaHiromi SatoAkihiro Hisaka

Published in: Clinical pharmacokinetics (2021)

Hepatic clearance consistently decreased by 0.80% per year from the age of 40 years, with aging for multiple drugs analyzed in this study. Changes in organ weight and blood flow are considered to be primarily responsible for the age-related changes in hepatic and renal clearance.

Keyphrases

blood flow
body mass index
weight loss
physical activity
weight gain
body weight