Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk.

Calogerina CatalanoMiguel Inacio da Silva FilhoChristoph FrankShun LuKaterina JiraskovaVeronika VymetalkovaMiroslav LevyVaclav LiskaOndrej VycitalAlessio NaccaratiLudmila VodickovaKari HemminkiPavel VodickaAlexander N R WeberAsta Försti

Published in: Cancer medicine (2019)

Our data suggest that epistatic interactions and a high number of risk alleles may play an important role in CRC carcinogenesis, offering novel biological understanding for the CRC management.

Keyphrases

immune response
toll like receptor
inflammatory response
copy number
electronic health record
dendritic cells
nuclear factor