Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival.

Daniel Antunes MorenoLuciane Sussuchi da SilvaIsabella GomesLetícia Ferro LealGustavo Noriz BerardinelliGisele Melo GonçalvesCaio Augusto PereiraIara Viana Vidigal SantanaMarcus de Medeiros MatsushitaKrishna BhatSean LawlerRui Manuel Vieira Reis

Published in: Therapeutic advances in medical oncology (2022)

GBM patients. Increased immune functions, CD45, cytotoxic cells, and macrophage scores were associated with a more aggressive phenotype and may provide promising possibilities for therapy. Moreover, a 12 gene-based signature could predict patients' prognosis.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
squamous cell carcinoma
gene expression
induced apoptosis
oxidative stress
bone marrow
cell death
copy number
smoking cessation
endoplasmic reticulum stress