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Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+ 4/CD44+ prostate cancer stem cells.

Z BinalE AçıkgözFuat KızılayG ÖktemB Altay
Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)
The increase in a number of genes associated with ribosome biogenesis, translation, and mTOR signaling may be important to evaluate prognosis and determine treatment approach for prostate cancer (PCa). A better understanding of the molecular pathways associated with CSCs may be promising to develop targeted therapies to prolong survival in PCa.
Keyphrases
  • prostate cancer
  • stem cells
  • radical prostatectomy
  • cell proliferation
  • combination therapy
  • free survival
  • single molecule
  • cancer stem cells
  • bone marrow