Control of Inflammatory Response by Tissue Microenvironment.

Zhongyang WuScott D PopeNasiha S AhmedDiana L LeungStephanie HajjarQiuyu YueDiya M AnandElizabeth B KoppDaniel OkinWeiyi MaJonathan C KaganDiana C HargreavesRuslan MedzhitovXu Zhou

Published in: bioRxiv : the preprint server for biology (2024)

Acidic pH regulates a switch-like gene-specific inflammatory response in macrophagesAcidic pH impacts chromatin remodeling and transcription circuits to control inflammatory programsBRD4 transcriptional condensates are regulated by intracellular pH via pH-sensitive motifs located within the intrinsically disordered regionTissue inflammation decreases intracellular pH and disrupts BRD4 condensates as a negative feedback.

Keyphrases

inflammatory response
transcription factor
oxidative stress
lipopolysaccharide induced
gene expression
lps induced
genome wide
stem cells
dna damage
immune response