Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals.
Kristine TveitMonica HermannRoy Miodini NilsenSusanna M WallerstedtArvid RongveEspen MoldenKristine HolePublished in: European journal of clinical pharmacology (2024)
The age-related increase in C/D ratio starts in middle-aged adults and progresses up to more than twofold higher C/D ratio in the oldest old. Sertraline seems to be less prone to age-related changes in C/D ratio than the other antidepressants.